![]() The authors of this study suggest that there are two major components of the diet that can affect intestinal permeability: fructose and fat. ![]() Dietary Effects on Leaky Gutīesides just the composition of gut bacteria, nutritional factors play an important role in permeability as well. This demonstrates the benefits of a balanced microbiota in the gut to maintain the function of the intestinal barrier, particularly in obesity. Probiotics can have anti-inflammatory effects in the gut, regulating the production of inflammatory cytokines and reducing intestinal permeability. Probiotic supplementation can help strengthen the tight junctions of the intestine, reducing overall permeability. Small intestinal bacterial overgrowth (SIBO) may also play a role in intestinal permeability by increasing constipation, reducing pancreatic enzyme and gastric acid activity, and disturbing the microbiota and host immune system relationship. One theory is that the metabolic activity of gut microbiota contributes to weight gain by causing more calories to be extracted from the food passing through the gut. While it is uncertain whether the alterations in gut health are the cause or consequence of obesity, the association between dysbiosis and obesity is strong. Recently, a group of researchers in Brazil published a new review exploring the idea that intestinal permeability is a contributing factor to obesity. Is healing your gut the hidden key to weight loss? While the existence of leaky gut syndrome is still debated among doctors and scientists, it is clear to me that having healthy gut bacteria is crucial to maintaining a normal weight and functional metabolism. ![]() I’ve been writing about the connection between gut health and “diabesity” for quite some time now I have an entire series on diabesity and metabolic syndrome on my website dedicated to the relationships between obesity, insulin resistance, metabolic syndrome and type 2 diabetes, and I believe that inflammation and leaky gut caused by gut dysbiosis are the key players in this metabolic epidemic. This is a serious health problem for many Americans – one that isn’t going away any time soon – and determining the cause of these metabolic conditions is a top priority for obesity researchers across the country. ( 1) This disease, characterized by long term low-grade inflammation, causes metabolic disturbances that lead to the development of complications such as nonalcoholic fatty liver disease, cardiovascular disease, and type 2 diabetes. It’s no secret that obesity, diabetes, and metabolic disease are afflicting an incredible number of Americans in fact, the prevalence of the metabolic syndrome in our country has reached an astonishing 34% and is continuing to rise.
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